Structural mass spectrometry of proteins using hydroxyl radical based protein footprinting.
نویسندگان
چکیده
Structural MS is a rapidly growing field with many applications in basic research and pharmaceutical drug development. In this feature article the overall technology is described and several examples of how hydroxyl radical based footprinting MS can be used to map interfaces, evaluate protein structure, and identify ligand dependent conformational changes in proteins are described.
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ورودعنوان ژورنال:
- Analytical chemistry
دوره 83 19 شماره
صفحات -
تاریخ انتشار 2011